TY - JOUR
T1 - Insights into organoid-based modeling of COVID-19 pathology
AU - Boroojerdi, Mohadese Hashem
AU - Al Jabry, Tariq
AU - Mirarefin, Seyed Mohamad Javad
AU - Albalushi, Halima
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/2/25
Y1 - 2023/2/25
N2 - Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.
AB - Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.
KW - COVID-19
KW - Organoid
KW - Regenerative medicine
KW - SARS-CoV-2
KW - Stem cell
KW - COVID-19 Drug Treatment
KW - Organoids
KW - Humans
UR - http://www.scopus.com/inward/record.url?scp=85148998730&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85148998730&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/48bd2bdb-ed28-3c4e-b614-b16ea00c8771/
U2 - 10.1186/s12985-023-01996-2
DO - 10.1186/s12985-023-01996-2
M3 - Article
C2 - 36841795
AN - SCOPUS:85148998730
SN - 1743-422X
VL - 20
SP - 37
JO - Virology Journal
JF - Virology Journal
IS - 1
M1 - 37
ER -