Influence of urocortin and corticotropin releasing factor on venous tone in conscious rats

Aly M. Abdelrahman, Su Lin Lim, Catherine C.Y. Pang*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

17 اقتباسات (Scopus)

ملخص

The corticotropin releasing factor (CRF) family includes CRF and urocortin. The effects of urocortin and CRF (0.3, 1, 3 and 10 nmol/kg, i.v.) relative to those of vehicle (0.9% NaCl) on mean arterial pressure and mean circulatory filling pressure (index of venous tone) were examined in conscious, unrestrained rats that were either intact (unblocked) or ganglion-blocked by treatment with mecamylamine (10 mg/kg, i.v.) followed by noradrenaline (4 μg/kg/min, i.v.) to increase vasomotor tone. Both urocortin and CRF dose-dependently decreased mean arterial pressure in intact rats and ganglion-blocked rats. The depressor action of urocortin was greater than that of CRF at all doses. In intact rats, neither compound reduced mean circulatory filling pressure. In ganglion-blocked rats, urocortin and the highest dose of CRF decreased mean circulatory filling pressure. In conclusion, both urocortin and CRF are vasodepressor agents with venodilator action.

اللغة الأصليةEnglish
الصفحات (من إلى)107-111
عدد الصفحات5
دوريةEuropean Journal of Pharmacology
مستوى الصوت510
رقم الإصدار1-2
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مارس 7 2005

ASJC Scopus subject areas

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