TY - JOUR
T1 - Influence of age on prognosis of young patients with uveal melanoma
T2 - A matched retrospective cohort study
AU - Kaliki, Swathi
AU - Shields, Carol L.
AU - Mashayekhi, Arman
AU - Ganesh, Anuradha
AU - Furuta, Minoru
AU - Shields, Jerry A.
PY - 2013
Y1 - 2013
N2 - Purpose. To determine the influence of patient age on life prognosis in patients with uveal melanoma. Design. Matched retrospective cohort study of 122 patients in each age category (young [≤20 years], mid-adults [21-60 years], older adults [>60 years]). Results. Kaplan-Meier estimates of tumor-related metastasis at 3, 5, and 10 years were 1%, 8%, and 8% in young; 8%, 11%, and 26% in mid-adults; and 13%, 16%, and 24% in older adults. After exclusion of iris melanoma, Kaplan-Meier estimates of tumor-related metastasis at 3, 5, and 10 years were 2%, 11%, and 18% in young; 9%, 14%, and 21% in mid-adults; and 9%, 34%, and 33% in older adults. Risk factors for metastasis based on multivariate analysis included increasing age in young (p=0.05, hazard ratio [HR] 1.33), male gender in mid-adults (p=0.046, HR 4.23), and larger tumor basal diameter in mid-adults (p=0.002, HR 1.37) and older adults (p=0.001, HR 1.30). After adjusting for tumor diameter, the metastatic rate was lower in young patients compared to mid-adults (0=0.042, HR 3.00) and older adults (p=0.007, HR 4.20). Conclusions. Younger patient age at the time of diagnosis of uveal melanoma is associated with lower rate of metastasis compared to mid-adults and older adults.
AB - Purpose. To determine the influence of patient age on life prognosis in patients with uveal melanoma. Design. Matched retrospective cohort study of 122 patients in each age category (young [≤20 years], mid-adults [21-60 years], older adults [>60 years]). Results. Kaplan-Meier estimates of tumor-related metastasis at 3, 5, and 10 years were 1%, 8%, and 8% in young; 8%, 11%, and 26% in mid-adults; and 13%, 16%, and 24% in older adults. After exclusion of iris melanoma, Kaplan-Meier estimates of tumor-related metastasis at 3, 5, and 10 years were 2%, 11%, and 18% in young; 9%, 14%, and 21% in mid-adults; and 9%, 34%, and 33% in older adults. Risk factors for metastasis based on multivariate analysis included increasing age in young (p=0.05, hazard ratio [HR] 1.33), male gender in mid-adults (p=0.046, HR 4.23), and larger tumor basal diameter in mid-adults (p=0.002, HR 1.37) and older adults (p=0.001, HR 1.30). After adjusting for tumor diameter, the metastatic rate was lower in young patients compared to mid-adults (0=0.042, HR 3.00) and older adults (p=0.007, HR 4.20). Conclusions. Younger patient age at the time of diagnosis of uveal melanoma is associated with lower rate of metastasis compared to mid-adults and older adults.
KW - Children
KW - Eye
KW - Melanoma
KW - Metastasis
KW - Pediatric
KW - Prognosis
KW - Tumor
KW - Uvea
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U2 - 10.5301/ejo.5000200
DO - 10.5301/ejo.5000200
M3 - Article
C2 - 23065853
AN - SCOPUS:84874169349
SN - 1120-6721
VL - 23
SP - 208
EP - 216
JO - European Journal of Ophthalmology
JF - European Journal of Ophthalmology
IS - 2
ER -