Improved treatment satisfaction and convenience with deferasirox in iron-overloaded patients with β-thalassemia: Results from the ESCALATOR trial

Ali Taher*, Abdullah Al Jefri, Mohsen Saleh Elalfy, Kusai Al Zir, Shahina Daar, Diana Rofail, Jean François Baladi, Dany Habr, Ulrike Kriemler-Krahn, Amal El-Beshlawy

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

39 اقتباسات (Scopus)

ملخص

Patient-reported outcomes of once-daily oral deferasirox (Exjade®) in iron-overloaded patients with β-thalassemia not achieving successful chelation with prior deferoxamine and/or deferiprone were investigated in a prospective, open-label, 1-year, multicenter study in the Middle East (ESCALATOR). The initial dose of deferasirox was 20 mg/kg/day, with subsequent dose adjustments. At baseline and the end of study (EOS), patients (n = 237) completed a 5-point rating scale for treatment satisfaction and convenience, and recorded time lost to treatment. At EOS, 90.7% of patients were 'satisfied'/'very satisfied' with their iron chelation therapy (ICT) versus 23.2% at baseline. 92.8% (EOS) versus 21.5% (baseline) of patients considered their therapy to be 'convenient'/'very convenient'. Time lost to therapy for daily activities was substantially reduced (3.2 ± 8.6 [mean ± SD; EOS] vs. 30.1 ± 44.2 [baseline] h/month). Patients reported greater satisfaction and convenience, and lower impact on daily activities, with deferasirox than with previous ICT. This may help improve adherence to lifelong ICT in iron-overloaded β-thalassemia patients.

اللغة الأصليةEnglish
الصفحات (من إلى)220-225
عدد الصفحات6
دوريةActa Haematologica
مستوى الصوت123
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مايو 2010

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