Impact of Clopidogrel on Mortality in Patients With Acute Heart Failure Stratified by Coronary Artery Disease: Findings From the Arabian Gulf Acute Heart Failure Registry (Gulf CARE)

Ibrahim Al-Zakwani*, Prashanth Panduranga, Jawad A. Al-Lawati, Kadhim Sulaiman, Alawi A. Alsheikh-Ali, Khalid F. AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Omar Alnobani, Ahmed Al-Motarreb, Mustafa Ridha, Bassam Bulbanat, Mohammed Al-Jarallah, Nooshin Bazargani, Nidal Asaad, Haitham Amin

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

ملخص

We evaluated the impact of clopidogrel use on 3- and 12-months all-cause mortality in patients with acute heart failure (AHF) stratified by coronary artery disease (CAD) in patients admitted to 47 hospitals in 7 Middle Eastern countries with AHF from February to November 2012. Clopidogrel use was associated with significantly lower risk of all-cause mortality at 3 months (adjusted odds ratio [aOR], 0.61; 95% confidence interval [CI]: 0.42-0.87; P =.007) and 12 months (aOR, 0.61; 95% CI: 0.47-0.79; P <.001). When the analysis was stratified by CAD, the clopidogrel group in those with AHF and CAD was also associated with significantly lower risk of all-cause mortality at 3 months (aOR, 0.56; 95% CI: 0.38-0.83; P =.003) and 12 months (aOR, 0.58; 95% CI: 0.44-0.77; P <.001). However, in AHF patients without CAD, clopidogrel use was not associated with any survival advantages, neither at 3 months (aOR, 0.99; 95% CI: 0.32-3.11; P =.987) nor at 12 months (aOR, 0.80; 95% CI: 0.37-1.72; P =.566). Clopidogrel use was associated with short- and long-term all-cause mortality in patients with AHF and CAD. In AHF patients without CAD, clopidogrel use did not offer any survival advantage.

اللغة الأصليةEnglish
الصفحات (من إلى)884-891
عدد الصفحات8
دوريةAngiology
مستوى الصوت69
رقم الإصدار10
المعرِّفات الرقمية للأشياء
حالة النشرPublished - نوفمبر 1 2018

ASJC Scopus subject areas

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بصمة

أدرس بدقة موضوعات البحث “Impact of Clopidogrel on Mortality in Patients With Acute Heart Failure Stratified by Coronary Artery Disease: Findings From the Arabian Gulf Acute Heart Failure Registry (Gulf CARE)'. فهما يشكلان معًا بصمة فريدة.

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