Hydroxyurea or chronic exchange transfusions in patients with sickle cell disease: Role of transcranial doppler ultrasound in stroke prophylaxis

Heba Suliman, Yasser Wali, Muna Al Saadoon, Mathew Zechariah, Ranjan R. William, Arunodaya Gujjar, Anil Pathare*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

7 اقتباسات (Scopus)

ملخص

Hydroxyurea is increasingly used in patients with sickle cell disease and acts by several underlying mechanisms. Its usage has been reported to eliminate transfusion needs in children with beta-thalassemia major. It has also been used in sickle cell disease patients on stroke prophylaxis with exchange transfusions who develop transfusional iron overload and is now being considered as a possible alternative to chronic transfusions for secondary stroke prophylaxis. Our case demonstrates a pitfall when using hydroxyurea without monitoring intracranial cerebral vessels for vasculopathic changes; presence of which can predict stroke risk and alert the need for chronic blood transfusions as primary stroke prophylaxis. Transcranial Doppler is a crucial investigation that can reveal elevated cerebral arterial flow velocities.

اللغة الأصليةEnglish
الصفحات (من إلى)42-44
عدد الصفحات3
دوريةJournal of Pediatric Hematology/Oncology
مستوى الصوت31
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرPublished - يناير 2009

ASJC Scopus subject areas

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بصمة

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