Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance

Jessica Godin-Ethier, Sandy Pelletier, Laïla Aïcha Hanafi, Philippe O. Gannon, Marie Andrée Forget, Jean Pierre Routy, Mohamed Rachid Boulassel, Urszula Krzemien, Simon Tanguay, Jean Baptiste Lattouf, Nathalie Arbour, Réjean Lapointe*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

44 اقتباسات (Scopus)

ملخص

Previous cancer vaccination approaches have shown some efficiency in generating measurable immune responses, but they have rarely led to tumor regression. It is therefore possible that tumors emerge with the capacity to down-regulate immune counterparts, through the local production of immunosuppressive molecules, such as IDO. Although it is known that IDO exerts suppressive effects on T cell functions, the mechanisms of IDO regulation in tumor cells remain to be characterized. Here, we demonstrate that activated T cells can induce functional IDO expression in breast and kidney tumor cell lines, and that this is partly attributable to IFN-γ. Moreover, we found that IL-13, a Th2 cytokine, has a negative modulatory effect on IDO expression. Furthermore, we report IDO expression in the majority of breast and kidney carcinoma samples, with infiltration of activated Th1-polarized T cells in human tumors. These findings demonstrate complex control of immune activity within tumors. Future immune therapeutic interventions should thus include strategies to counteract these negative mechanisms.

اللغة الأصليةEnglish
الصفحات (من إلى)7752-7760
عدد الصفحات9
دوريةJournal of Immunology
مستوى الصوت183
رقم الإصدار12
المعرِّفات الرقمية للأشياء
حالة النشرPublished - ديسمبر 15 2009
منشور خارجيًانعم

ASJC Scopus subject areas

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