TY - JOUR
T1 - High levels of Zinc-α-2-Glycoprotein among Omani AIDS patients on combined antiretroviral therapy
AU - Hasson, Sidgi Syed Anwer
AU - Al-Balushi, Mohammed Saeed
AU - Al Yahmadi, Muzna Hamed
AU - Al-Busaidi, Juma Zaid
AU - Said, Elias Antony
AU - Othman, Mohammed Shafeeq
AU - Sallam, Talal Abdullah
AU - Idris, Mohammed Ahmad
AU - Al-Jabri, Ali Abdullah
N1 - Funding Information:
Foundation Project: Supported by the Research Council of the Sultanate of Oman (RC/MED/MICR/11/01) and the College of Medicine and Health Sciences, Sultan Qaboos University (Internal-Grant/2013), Oman.
Funding Information:
Acknowledgment is extended to AIDS patients who donated their blood kindly with their consent for this project, and Dr. Abdullah Balkhair. This study is supported by the Research Council of the Sultanate of Oman (RC/MED/MICR/11/01) and the College of Medicine and Health Sciences, Sultan Qaboos University (Internal-Grant/2013), Oman.
Publisher Copyright:
© 2014 by the Asian Pacific Journal of Tropical Biomedicine.
PY - 2014
Y1 - 2014
N2 - Objective: To investigate the levels of zinc-α-2-glycoprotein (ZAG) among Omani AIDS patients receiving combined antiretroviral therapy (cART). Methods: A total of 80 Omani AIDS patients (45 males and 35 females), average age of 36 years, who were receiving cART at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, were tested for the levels of ZAG. In addition, 80 healthy blood donors (46 males and 34 females), average age of 26 years, attending the SQUH Blood Bank, were tested in parallel as a control group. Measurement of the ZAG levels was performed using a competitive enzyme-linked immunosorbent assay and in accordance with the manufacturer's instructions. Results: The ZAG levels were found to be significantly higher among AIDS patients compared to the healthy individuals (P=0.033). A total of 56 (70%) of the AIDS patients were found to have higher levels of ZAG and 16 (20%) AIDS patients were found to have high ZAG levels, which are significantly (P > 0.031) associated with weight loss. Conclusions: ZAG levels are high among Omani AIDS patients on cART and this necessitates the measurement of ZAG on routine basis, as it is associated with weight loss.
AB - Objective: To investigate the levels of zinc-α-2-glycoprotein (ZAG) among Omani AIDS patients receiving combined antiretroviral therapy (cART). Methods: A total of 80 Omani AIDS patients (45 males and 35 females), average age of 36 years, who were receiving cART at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, were tested for the levels of ZAG. In addition, 80 healthy blood donors (46 males and 34 females), average age of 26 years, attending the SQUH Blood Bank, were tested in parallel as a control group. Measurement of the ZAG levels was performed using a competitive enzyme-linked immunosorbent assay and in accordance with the manufacturer's instructions. Results: The ZAG levels were found to be significantly higher among AIDS patients compared to the healthy individuals (P=0.033). A total of 56 (70%) of the AIDS patients were found to have higher levels of ZAG and 16 (20%) AIDS patients were found to have high ZAG levels, which are significantly (P > 0.031) associated with weight loss. Conclusions: ZAG levels are high among Omani AIDS patients on cART and this necessitates the measurement of ZAG on routine basis, as it is associated with weight loss.
KW - AIDS
KW - Combined antiretroviral therapy
KW - Levels
KW - Oman
KW - Patients
KW - Zinc-α-2-glycoprotein
UR - http://www.scopus.com/inward/record.url?scp=84922650280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922650280&partnerID=8YFLogxK
U2 - 10.12980/APJTB.4.201414B126
DO - 10.12980/APJTB.4.201414B126
M3 - Article
C2 - 25183329
AN - SCOPUS:84922650280
SN - 2221-1691
VL - 4
SP - 610
EP - 613
JO - Asian Pacific Journal of Tropical Biomedicine
JF - Asian Pacific Journal of Tropical Biomedicine
IS - 8
ER -