ملخص
Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance genepfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance.
اللغة الأصلية | English |
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الصفحات (من إلى) | 1535-1538 |
عدد الصفحات | 4 |
دورية | Journal of Infectious Diseases |
مستوى الصوت | 183 |
رقم الإصدار | 10 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - مايو 15 2001 |
منشور خارجيًا | نعم |
ASJC Scopus subject areas
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