High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1

Hamza A. Babiker, S. J. Pringle, A. Abdel-Muhsin, M. Mackinnon, P. Hunt, D. Walliker

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

221 اقتباسات (Scopus)

ملخص

Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance genepfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance.

اللغة الأصليةEnglish
الصفحات (من إلى)1535-1538
عدد الصفحات4
دوريةJournal of Infectious Diseases
مستوى الصوت183
رقم الإصدار10
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مايو 15 2001
منشور خارجيًانعم

ASJC Scopus subject areas

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بصمة

أدرس بدقة موضوعات البحث “High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1'. فهما يشكلان معًا بصمة فريدة.

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