Global DNA methylation and tumor suppressor gene promoter methylation and gastric cancer risk in an Omani Arab population

Jennifer A. Rusiecki*, Maryam Al-Nabhani, Letizia Tarantini, Ligong Chen, Andrea Baccarelli, Mansour S. Al-Moundhri

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

17 اقتباسات (Scopus)

ملخص

Aim: We carried out a case-control study in an Omani Arab population to investigate the association between gastric cancer and peripheral blood leukocyte DNA methylation in LINE-1 and in the tumor suppressor genes CDH1, p16, TP53 and RUNX3. Materials & methods: We quantified methylation (%5-mC) in DNA extracted from peripheral blood leukocytes via pyrosequencing. We calculated odds ratios (ORs) and 95% CIs using logistic regression. Results: We found patterns of global hypomethylation (LINE-1: OR continuous = 0.59; 95% CI: 0.42-0.82) and TP53 promoter hypomethylation (OR continuous = 0.64; 95% CI: 0.16-0.85) for cases versus controls; p16 promoter region hypomethylation was not statistically significant. Evaluating LINE-1, TP53 and p16 jointly yielded a more pronounced negative association with gastric cancer (OR: 0.24; 95% CI: 0.09-0.66). Age was a significant effect modifier. We found no differences by tumor grade, stage or histology. Conclusion: We found a pattern of global hypomethylation and promoter region hypomethylation of TP53 and p16 in cases versus controls for this population of Omani Arabs.

اللغة الأصليةEnglish
الصفحات (من إلى)417-429
عدد الصفحات13
دوريةEpigenomics
مستوى الصوت3
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أغسطس 2011

ASJC Scopus subject areas

  • ???subjectarea.asjc.1300.1311???
  • ???subjectarea.asjc.1300.1306???

بصمة

أدرس بدقة موضوعات البحث “Global DNA methylation and tumor suppressor gene promoter methylation and gastric cancer risk in an Omani Arab population'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا