Further evidence for papovavirus as the probable etiology of transmissible lymphoma of Syrian hamsters.

S. W. Barthold*, P. N. Bhatt, E. A. Johnson

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

21 اقتباسات (Scopus)

ملخص

The role of hamster papovavirus as the etiology of transmissible lymphoma was investigated under strict conditions that prevented natural exposure to the lymphoma agent. In an initial experiment, 19 hamsters that were exposed naturally to transmissible lymphoma were placed in direct and indirect contact with weanling hamsters from an uninfected source. Lymphoma developed in the original infected hamsters as well as hamsters maintained in direct and indirect contact. In addition, one of the contact hamsters developed cutaneous epitheliomas, containing hamster papovavirus. Epithelioma homogenate was inoculated into primary hamster embryo cultures, in which hamster papovavirus replicated. Second and third passage tissue culture fluid containing hamster papovavirus induced lymphomas in suckling and weanling hamsters. Cell culture fluid from uninoculated embryo cultures was not oncogenic.

اللغة الأصليةEnglish
الصفحات (من إلى)283-288
عدد الصفحات6
دوريةLaboratory animal science Chicago
مستوى الصوت37
رقم الإصدار3
حالة النشرPublished - يونيو 1987

ASJC Scopus subject areas

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بصمة

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