Forecasting hemoglobinopathy burden through neonatal screening in Omani neonates

Salam Alkindi, Shoaib Al Zadjali, Ali Al Madhani, Shahina Daar, Hamood Al Haddabi, Qamariya Al Abri, David Gravell, Tsouria Berbar, Sahaya Pravin, Anil Pathare, Rajagopal Krishnamoorthy*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

60 اقتباسات (Scopus)

ملخص

To evaluate the incidence of hemoglobinopathies in Omani subjects and to forecast its future burden on health resources, we initiated a prospective neonatal screening program in two major cities of the Sultanate of Oman. Consecutive cord blood samples from a total of 7,837 neonates were analyzed for complete blood counts and for hemoglobin (Hb) profile by high performance liquid chromatography (HPLC). No case with Hb H (β4) was detected. We observed that the overall incidence of α-thalassemia (α-thal) was 48.5 [based on the presence of Hb Bart's (γ4)] and the β-globin-related abnormalities accounted for 9.5 of the samples (4.8 sickle cell trait, 2.6 β-thal trait, 0.9 Hb E trait, 0.8 Hb D trait, 0.08 Hb C trait, 0.3 sickle cell disease and 0.08 homozygous β-thal). This is also the first large study to establish reference ranges of cord red blood cell (RBC) indices for Omani neonates.

اللغة الأصليةEnglish
الصفحات (من إلى)135-144
عدد الصفحات10
دوريةHemoglobin
مستوى الصوت34
رقم الإصدار2
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أبريل 2010

ASJC Scopus subject areas

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بصمة

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