TY - JOUR
T1 - Follicular dendritic cell sarcoma
T2 - Cytogenetics and pathological findings
AU - Udayakumar, Achandira M.
AU - Al-Bahri, Maiya
AU - Burney, Ikram A.
AU - Al-Haddabi, Ibrahim
N1 - Publisher Copyright:
© 2015, Sultan Qaboos University. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm with a non-specific and insidious presentation further complicated by the difficult diagnostic and therapeutic assessment. It has a low to intermediate risk of recurrence and metastasis. Unlike other soft tissue sarcomas or histiocytic and dendritic cell neoplasms, cytogenetic studies are very limited in FDCS cases. Although no specific chromosomal marker has yet been established, complex aberrations and different ploidy types have been documented. We report the case of a 39-yearold woman with FDCS who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in February 2013. Ultrastructural, immunophenotypical and histological findings are reported. In addition, karyotypic findings showed deletions of the chromosomes 1p, 3q, 6q, 7q, 8q and 11q. To the best of the authors’ knowledge, these have not been reported previously in this tumour.
AB - Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm with a non-specific and insidious presentation further complicated by the difficult diagnostic and therapeutic assessment. It has a low to intermediate risk of recurrence and metastasis. Unlike other soft tissue sarcomas or histiocytic and dendritic cell neoplasms, cytogenetic studies are very limited in FDCS cases. Although no specific chromosomal marker has yet been established, complex aberrations and different ploidy types have been documented. We report the case of a 39-yearold woman with FDCS who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in February 2013. Ultrastructural, immunophenotypical and histological findings are reported. In addition, karyotypic findings showed deletions of the chromosomes 1p, 3q, 6q, 7q, 8q and 11q. To the best of the authors’ knowledge, these have not been reported previously in this tumour.
KW - Case report
KW - Chromosomal aberrations
KW - Cytogenetics
KW - Fine needle aspiration
KW - Follicular dendritic cell sarcoma
KW - Karyotyping
KW - Oman
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U2 - 10.18295/squmj.2015.15.03.017
DO - 10.18295/squmj.2015.15.03.017
M3 - Article
C2 - 26355964
AN - SCOPUS:84940021398
SN - 2075-051X
VL - 15
SP - e411-e414
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
IS - 3
ER -