First pass FDG measured blood flow in tumors: A comparison with O-15 labeled water measured blood flow

N. A. Mullani, R. S. Herbst, J. L. Abbruzzese, B. Barron, L. Lamki, C. Charnsangavej, E. Kim, H. T. Tran, A. Jiwani, K. L. Gould

نتاج البحث: المساهمة في مجلةمراجعة النظراء

14 اقتباسات (Scopus)

ملخص

The purpose of this study was to determine if the first-pass of FDG can be used to measure regional blood flow in tumors in the absence of perfusion imaging with a known blood flow tracer. PET scans were obtained in patients being evaluated for tumor perfusion and metabolism in a Phase I dose escalating protocol for Endostatin, a novel antiangiogenic agent. A two minutes perfusion scan was done with a bolus injection of 60 mCi of O-15 labeled water followed by a 10 mCi dose of FDG and four sequential scans consisting of a first pass two minutes scan and three 15 minutes scans. Regions of interest were drawn on two tumor sites for each scan. Blood flow was computed using a one-compartment model previously published by the authors. Linear regression analysis was carried out between the first pass FDG measured blood flow and O-15 measured blood flow (Figure 1). (Figure Presented) (5K) Figure 1. Blood flow estimated from the first pass of FDG was linearly correlated with 0-15 measured blood flow with an intercept of 0.01, slope of 0.86, and r squared regression coefficient of 0.74 (R = 0.86) for blood flow values of up to 0.6 ml/min/gm of tissue. These results suggests that in the absence of a perfusion tracer, the first pass of FDG provides an estimate of perfusion in a tumor within the limitations of incomplete extraction of FDG compared to O-15 water.

اللغة الأصليةEnglish
الصفحات (من إلى)153
عدد الصفحات1
دوريةClinical Positron Imaging (Netherlands)
مستوى الصوت3
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 2000

ASJC Scopus subject areas

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