Experimental design for binary data

Models for binary data are usually such that the information matrix depends on the unknown parameters. Thus the standard criteria for optimality in regression experiments cannot be applied without modification. Methods of going around this difficulty include the use of initial point estimates, sequential methods, and Bayesian analysis. This article is mainly concerned with the robustness and the number of design points for methods involving initial estimates, and for sequential methods in a small number of stages. A final section discusses the criterion of constant information for models involving one or two parameters, and summarizes recent results in this field.