TY - JOUR
T1 - Effect of porous media of the stenosed artery wall to the coronary physiological diagnostic parameter
T2 - A computational fluid dynamic analysis
AU - Govindaraju, Kalimuthu
AU - Kamangar, Sarfaraz
AU - Badruddin, Irfan Anjum
AU - Viswanathan, Girish N.
AU - Badarudin, A.
AU - Salman Ahmed, N. J.
N1 - Funding Information:
The authors would like to thank University of Malaya for funding the research under grant number RP006A-13AET and ER026-2011A . The authors gratefully acknowledge the facilities provided by HELP College of Arts and Technology (HELP CAT), a member of the HELP Group. Thanks also to Lam Pei Qi from HELP CAT for helping our research activities.
PY - 2014/4
Y1 - 2014/4
N2 - Functional assessment of a coronary artery stenosis severity is generally assessed by fractional flow reserve (FFR), which is calculated from pressure measurements across the stenosis. The purpose of this study is to investigate the effect of porous media of the stenosed arterial wall on this diagnostic parameter. To understand the role of porous media on the diagnostic parameter FFR, a 3D computational simulations of the blood flow in rigid and porous stenotic artery wall models are carried out under steady state and transient conditions for three different percentage area stenoses (AS) corresponding to 70% (moderate), 80% (intermediate), and 90% (severe). Blood was modeled as a non Newtonian fluid. The variations of pressure drop across the stenosis and diagnostic parameter were studied in both models.The FFR decreased in proportion to the increase in the severity of the stenosis. The relationship between the percentage AS and the FFR was non linear and inversely related in both the models. The cut-off value of 0.75 for FFR was observed at 81.89% AS for the rigid artery model whereas 83.61% AS for the porous artery wall model. This study demonstrates that the porous media consideration on the stenotic arterial wall plays a substantial role in defining the cut-off value of FFR. We conclude that the effect of porous media on FFR, could lead to misinterpretation of the functional severity of the stenosis in the region of 81.89 %-83.61% AS.
AB - Functional assessment of a coronary artery stenosis severity is generally assessed by fractional flow reserve (FFR), which is calculated from pressure measurements across the stenosis. The purpose of this study is to investigate the effect of porous media of the stenosed arterial wall on this diagnostic parameter. To understand the role of porous media on the diagnostic parameter FFR, a 3D computational simulations of the blood flow in rigid and porous stenotic artery wall models are carried out under steady state and transient conditions for three different percentage area stenoses (AS) corresponding to 70% (moderate), 80% (intermediate), and 90% (severe). Blood was modeled as a non Newtonian fluid. The variations of pressure drop across the stenosis and diagnostic parameter were studied in both models.The FFR decreased in proportion to the increase in the severity of the stenosis. The relationship between the percentage AS and the FFR was non linear and inversely related in both the models. The cut-off value of 0.75 for FFR was observed at 81.89% AS for the rigid artery model whereas 83.61% AS for the porous artery wall model. This study demonstrates that the porous media consideration on the stenotic arterial wall plays a substantial role in defining the cut-off value of FFR. We conclude that the effect of porous media on FFR, could lead to misinterpretation of the functional severity of the stenosis in the region of 81.89 %-83.61% AS.
KW - Blood flow
KW - Computational fluid dynamics
KW - Coronary disease
KW - FFR
KW - Porosity and permeability
KW - Stenosis
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U2 - 10.1016/j.atherosclerosis.2014.01.043
DO - 10.1016/j.atherosclerosis.2014.01.043
M3 - Article
C2 - 24549189
AN - SCOPUS:84896291105
SN - 0021-9150
VL - 233
SP - 630
EP - 635
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -