ملخص
Intracellular photorelease of Ca2+ demonstrated the presence of Ca2+-activated K+ channels in smooth muscle cells isolated from different locations of the rat pulmonary arterial tree. However, cell-free patch studies revealed marked differences in K+ channel distribution. In the main pulmonary artery the most frequently observed K+ channel was a ˜245pS conductance Ca2+- and ATP-activated (KCa, ATP) channel. In small pulmonary arteries two K+ channel types predominated: the KCa, ATP channel and a ˜185pS conductance K+ channel insensitive to intracellular Ca2+, ATP and voltage. This difference in K+ channel distribution may highlight a more complex regulatory mechanism for controlling membrane potential in small pulmonary arteries, reflecting their physiologically more important role in governing pulmonary vascular reactivity.
اللغة الأصلية | English |
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الصفحات (من إلى) | 183-189 |
عدد الصفحات | 7 |
دورية | Biochemical and Biophysical Research Communications |
مستوى الصوت | 208 |
رقم الإصدار | 1 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - 1995 |
منشور خارجيًا | نعم |
ASJC Scopus subject areas
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