Determination of ibuprofen in pharmaceutical formulations using time-resolved terbium-sensitized luminescence

Salma M.Z. Al-Kindy*, Fakhr Eldin O. Suliman

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

25 اقتباسات (Scopus)

ملخص

A sensitive and specific luminescence method for the determination of ibuprofen (IB) in pharmaceutical formulations in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb 3+) by formation of ternary complex with IB in the presence of tri-n-octylphosphine oxide (TOPO) and Tween-20 as surfactant. The luminescence signal for Tb-IB-TOPO is monitored at λex = 229 nm and λcm = 545 nm. Optimum conditions for the formation of the complex in aqueous system, were 16 mmol/L TRIS buffer, pH 5.7, TOPO 200 umol/L and 15 μmol/L of Tb3+, which allows for the determination of 9.7 × 10-7 - 9.7 × 10-6 mol/L IB with a detection limit of 1.2 × 10-7 mol/L. The relative standard deviations of the method were <1.4%, indicating excellent reproducibility. The proposed method was successfully applied for the assays of IB in pharmaceutical formulations with average recoveries of 100.3-102.5%.

اللغة الأصليةEnglish
الصفحات (من إلى)294-301
عدد الصفحات8
دوريةLuminescence
مستوى الصوت22
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 2007
منشور خارجيًانعم

ASJC Scopus subject areas

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