Design, Synthesis, and Testing of Potential Antisickling Agents. 10. (2, 2-Dimethylchroman-6-yl)alkanoic Acids

Majekodunmi O. Fatope*, Donald J. Abraham

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

11 اقتباسات (Scopus)

ملخص

Five (2,2-dimethylchroman-6-yl)alkanoic acids were synthesized and tested for antigelling activities. It was envisioned that these agents might bind via hydrophobic bonding to nonpolar sites of the “donor-acceptor” regions of hemoglobin S. Several (2,2-dimethylchroman-6-yl)alkanoic acids containing 1–4 carbon atoms on the side-chain residue were designed to interact at the acceptor site, were synthesized, and were found to be moderately potent antigelling agents. The weak activity observed for two of the acids at low concentrations is rationalized in terms of weak binding affinities or multiple binding to active and nonactive sites. The effect of these compounds on shifting the allosteric equilibrium was small or negligible. The low toxicity of one of the (2,2-dimethylchroman-6-yl)alkanoic acids demonstrates the potential use of yet another class of compounds that can be modified in the development of antisickling agents.

اللغة الأصليةEnglish
الصفحات (من إلى)1973-1977
عدد الصفحات5
دوريةJournal of Medicinal Chemistry
مستوى الصوت30
رقم الإصدار11
المعرِّفات الرقمية للأشياء
حالة النشرPublished - نوفمبر 1 1987
منشور خارجيًانعم

ASJC Scopus subject areas

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