TY - JOUR
T1 - De novo infantile primary antiphospholipid antibody syndrome
AU - Alshekaili, J.
AU - Reynolds, G.
AU - Cook, M. C.
PY - 2010/11
Y1 - 2010/11
N2 - Most autoimmune diseases are rare in infants. Early onset can represent an extreme phenotype arising from strong genetic predisposition relatively independent of environmental influence. Alternatively, neonatal autoimmunity can arise from transplacental passage of maternal pathogenic IgG autoantibodies. Distinguishing between these possible explanations is crucial for determining the prognosis in the specific patient, and has important implications for understanding pathogenesis. We report a case of neonatal thrombotic stroke associated with both cardiolipin and β2-glycoprotein I antibodies in neonatal serum but absent from cord blood and maternal serum. While the child also carried one prothrombotic allele of factor V (Leiden allele), which may have contributed to the risk of thromboembolic disease, the serological analysis represents unequivocal evidence of de novo neonatal primary phospholipid antibody syndrome.
AB - Most autoimmune diseases are rare in infants. Early onset can represent an extreme phenotype arising from strong genetic predisposition relatively independent of environmental influence. Alternatively, neonatal autoimmunity can arise from transplacental passage of maternal pathogenic IgG autoantibodies. Distinguishing between these possible explanations is crucial for determining the prognosis in the specific patient, and has important implications for understanding pathogenesis. We report a case of neonatal thrombotic stroke associated with both cardiolipin and β2-glycoprotein I antibodies in neonatal serum but absent from cord blood and maternal serum. While the child also carried one prothrombotic allele of factor V (Leiden allele), which may have contributed to the risk of thromboembolic disease, the serological analysis represents unequivocal evidence of de novo neonatal primary phospholipid antibody syndrome.
KW - Anticardiolipin antibodies
KW - antiphospholipid syndrome
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=78649249200&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649249200&partnerID=8YFLogxK
U2 - 10.1177/0961203310375263
DO - 10.1177/0961203310375263
M3 - Article
C2 - 20663842
AN - SCOPUS:78649249200
SN - 0961-2033
VL - 19
SP - 1565
EP - 1568
JO - Lupus
JF - Lupus
IS - 13
ER -