TY - JOUR
T1 - Criteria for diagnosis of familial hypercholesterolemia
T2 - A comprehensive analysis of the different guidelines, appraising their suitability in the Omani Arab population
AU - Al-Rasadi, Khalid
AU - Al-Waili, Khalid
AU - Al-Sabti, Hilal Ali
AU - Al-Hinai, Ali
AU - Al-Hashmi, Khamis
AU - Al-Zakwani, Ibrahim
AU - Banerjee, Yajnavalka
PY - 2014
Y1 - 2014
N2 - Subjects with Familial hypercholesterolemia are at increased risk for cardiac events such as premature myocardial infarction and early death from coronary heart disease, especially in patients with severe forms of the disease if left unattended. Therefore, there is an ardent need for the early diagnosis followed by aggressive therapeutic intervention and lifestyle modification. Three groups have developed clinical diagnostic tools for Familial hypercholesterolemia: the US MedPed Program, the Simon Broome Register Group in the United Kingdom, and the Dutch Lipid Clinic Network. In this article, the individual criteria are reviewed with particular emphasis on their advantage(s) and disadvantage(s), and in turn assess their suitability in diagnosing Familial hypercholesterolemia in the Omani Arab population. A brief insight into the process of "Cascade Screening" is also provided, this is a procedure that we are in the process of establishing in Oman.
AB - Subjects with Familial hypercholesterolemia are at increased risk for cardiac events such as premature myocardial infarction and early death from coronary heart disease, especially in patients with severe forms of the disease if left unattended. Therefore, there is an ardent need for the early diagnosis followed by aggressive therapeutic intervention and lifestyle modification. Three groups have developed clinical diagnostic tools for Familial hypercholesterolemia: the US MedPed Program, the Simon Broome Register Group in the United Kingdom, and the Dutch Lipid Clinic Network. In this article, the individual criteria are reviewed with particular emphasis on their advantage(s) and disadvantage(s), and in turn assess their suitability in diagnosing Familial hypercholesterolemia in the Omani Arab population. A brief insight into the process of "Cascade Screening" is also provided, this is a procedure that we are in the process of establishing in Oman.
KW - Cascade-screening
KW - Dutch criteria
KW - Familial hypercholesterolemia
KW - Omani Arab population
KW - Simon-broome criteria
KW - US-medped criteria
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U2 - 10.5001/omj.2014.22
DO - 10.5001/omj.2014.22
M3 - Review article
C2 - 24715932
AN - SCOPUS:84897143538
SN - 1999-768X
VL - 29
SP - 85
EP - 91
JO - Oman Medical Journal
JF - Oman Medical Journal
IS - 2
ER -