TY - GEN
T1 - Comparison of analytic and iterative reconstruction methods for quantitative cardiac PET studies in 3D using Oxygen-15 water scans
AU - Bouchareb, Yassine
AU - Thielemans, Kris
AU - Spinks, Terence
AU - Rimoldi, Ornella
AU - Camici, Paolo G.
PY - 2005
Y1 - 2005
N2 - We investigated the quantitative accuracy of iterative and analytic reconstruction methods to determine myocardial blood flow (MBF) in PET studies in pigs using O-15 labeled water. Dynamic scans were acquired on the EXACT3D PET scanner on large white pigs after H215O injection (resting and dipyridamole-induced stress). Radioactive microspheres were injected during the H215O scans to provide a "gold standard" of MBF values. Data were reconstructed with 3DRP, FORE + attenuation-weighted OSEM, FORE-FBP and 3D-OSEM. Factor images were generated by cluster analysis and linear dimension reduction (myocardium and left and right cavities) and resliced to short axis images; 16 ROIs were defined in the left myocardium and 2 ROIs in the left and right cavities. ROIs were projected onto the dynamic images to extract time-activity-curves (TACs), which were then fitted to a single compartment model to estimate regional and global absolute MBF. Microsphere measurements were obtained in a similar way and 64 pairs of measurements were made. FORE-OSEM and 3D-RP overestimated the CFR values by 10% and 17%, respectively and 3D-OSEM and FORE-FBP underestimate CFR values by 3% and 17%, respectively. Regression analysis for 3D-OSEM and FORE-OSEM gave intercepts close to zero and slopes close to unity. Bland and Altman plots of differences between all reconstructions and Microsphere provided a mean difference and limits of agreements in favour of 3D-OSEM and FORE-OSEM (mean difference closer to zero and smaller SD). For absolute quantification of MBF using O-15 water, 3D-OSEM and FORE-OSEM proved to be at least as accurate as 3DRP and FORE-FBP compared with the Microsphere technique.
AB - We investigated the quantitative accuracy of iterative and analytic reconstruction methods to determine myocardial blood flow (MBF) in PET studies in pigs using O-15 labeled water. Dynamic scans were acquired on the EXACT3D PET scanner on large white pigs after H215O injection (resting and dipyridamole-induced stress). Radioactive microspheres were injected during the H215O scans to provide a "gold standard" of MBF values. Data were reconstructed with 3DRP, FORE + attenuation-weighted OSEM, FORE-FBP and 3D-OSEM. Factor images were generated by cluster analysis and linear dimension reduction (myocardium and left and right cavities) and resliced to short axis images; 16 ROIs were defined in the left myocardium and 2 ROIs in the left and right cavities. ROIs were projected onto the dynamic images to extract time-activity-curves (TACs), which were then fitted to a single compartment model to estimate regional and global absolute MBF. Microsphere measurements were obtained in a similar way and 64 pairs of measurements were made. FORE-OSEM and 3D-RP overestimated the CFR values by 10% and 17%, respectively and 3D-OSEM and FORE-FBP underestimate CFR values by 3% and 17%, respectively. Regression analysis for 3D-OSEM and FORE-OSEM gave intercepts close to zero and slopes close to unity. Bland and Altman plots of differences between all reconstructions and Microsphere provided a mean difference and limits of agreements in favour of 3D-OSEM and FORE-OSEM (mean difference closer to zero and smaller SD). For absolute quantification of MBF using O-15 water, 3D-OSEM and FORE-OSEM proved to be at least as accurate as 3DRP and FORE-FBP compared with the Microsphere technique.
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U2 - 10.1109/NSSMIC.2005.1596753
DO - 10.1109/NSSMIC.2005.1596753
M3 - Conference contribution
AN - SCOPUS:33846647583
SN - 0780392213
SN - 9780780392212
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 2120
EP - 2123
BT - 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
T2 - Nuclear Science Symposium Conference Record, 2005 IEEE
Y2 - 23 October 2005 through 29 October 2005
ER -