TY - JOUR
T1 - Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats
AU - Ali, B. H.
AU - Cheng, Z.
AU - El Hadrami, G.
AU - Bashir, A. K.
AU - Mckellar, Q. A.
PY - 1996
Y1 - 1996
N2 - Paracetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes, Parent paracetamol had a significantly slower clearance (21.9 ± 1.4 mL/min·kg vs, 52.8 ± 7.3 mL/min·kg) (P < 0.01) in camels than in goats. In camels the predominant metabolite in plasma was the sulphate, although the ratios of glucuronide:paracetamol and sulphate:paracetamol were similar (5.20 ± 0.50 vs. 6.59 ± 0.51) following intravenous administration. In goats the glucuronide metabolite was the predominant moiety in plasma, and the area under the curve (AUC) of the sulphate was only 3.89% of that of the glucuronide conjugate, The apparent AUC for paracetamol in the camel following intramuscular administration was larger than that following intravenous administration, however, when the bioavailability (F) was determined, with correction for altered half-life, within the animal and between study phases it was 71 ± 17% in goats and 105 ± 26% in camels.
AB - Paracetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes, Parent paracetamol had a significantly slower clearance (21.9 ± 1.4 mL/min·kg vs, 52.8 ± 7.3 mL/min·kg) (P < 0.01) in camels than in goats. In camels the predominant metabolite in plasma was the sulphate, although the ratios of glucuronide:paracetamol and sulphate:paracetamol were similar (5.20 ± 0.50 vs. 6.59 ± 0.51) following intravenous administration. In goats the glucuronide metabolite was the predominant moiety in plasma, and the area under the curve (AUC) of the sulphate was only 3.89% of that of the glucuronide conjugate, The apparent AUC for paracetamol in the camel following intramuscular administration was larger than that following intravenous administration, however, when the bioavailability (F) was determined, with correction for altered half-life, within the animal and between study phases it was 71 ± 17% in goats and 105 ± 26% in camels.
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U2 - 10.1111/j.1365-2885.1996.tb00044.x
DO - 10.1111/j.1365-2885.1996.tb00044.x
M3 - Article
C2 - 8803883
AN - SCOPUS:0029898703
SN - 0140-7783
VL - 19
SP - 238
EP - 244
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
IS - 3
ER -