TY - JOUR
T1 - Comparative pharmacokinetics of metronidazole in camels, sheep and goats
AU - Ali, B. H.
AU - Charles, B. G.
AU - Al-Yousif, M.
AU - Bashir, A. K.
PY - 2003
Y1 - 2003
N2 - The pharmacokinetics of metronidazole was determined after a single intramuscular (i.m.) dose of 30 mg·kg-1-body weight in five camels, sheep and goats. Marked differences were found between the three species in some of the kinetic parameters. For example, the elimination half-lives (t1/2; h) in camels, sheep and goats were 10.0, 6.21 and 5.87, respectively. The drug maximum concentrations in plasma, Cmax (mg·ml-1), were 28.3, 54.6 and 54.4 in camels, sheep and goats. respectively. The time to reach Cmax, tmax (h), were 5, 4 and 2 in camels, sheep and goats, respectively. The mean residence times (MRT; h) in camels, sheep and goats were 16.7, 10.8 and 8.64, respectively. In the light of the present kinetic data and known microbial sensitivities of metronidazole, we recommend an i.m. dose of 15 mg·kg-1 in camels and 10 mg·kg-1 in sheep and goats, every 12 h.
AB - The pharmacokinetics of metronidazole was determined after a single intramuscular (i.m.) dose of 30 mg·kg-1-body weight in five camels, sheep and goats. Marked differences were found between the three species in some of the kinetic parameters. For example, the elimination half-lives (t1/2; h) in camels, sheep and goats were 10.0, 6.21 and 5.87, respectively. The drug maximum concentrations in plasma, Cmax (mg·ml-1), were 28.3, 54.6 and 54.4 in camels, sheep and goats. respectively. The time to reach Cmax, tmax (h), were 5, 4 and 2 in camels, sheep and goats, respectively. The mean residence times (MRT; h) in camels, sheep and goats were 16.7, 10.8 and 8.64, respectively. In the light of the present kinetic data and known microbial sensitivities of metronidazole, we recommend an i.m. dose of 15 mg·kg-1 in camels and 10 mg·kg-1 in sheep and goats, every 12 h.
KW - Antibacterials
KW - Antiprotozoals
KW - Kinetics
KW - Metronidazole
KW - Ruminants
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U2 - 10.2754/avb200372010049
DO - 10.2754/avb200372010049
M3 - Article
AN - SCOPUS:0037866637
SN - 0001-7213
VL - 72
SP - 49
EP - 53
JO - Acta Veterinaria Brno
JF - Acta Veterinaria Brno
IS - 1
ER -