Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists

Stefanie Weyler, Younis Baqi, Petra Hillmann, Marko Kaulich, Andrea M. Hunder, Ingrid A. Müller, Christa E. Müller*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

53 اقتباسات (Scopus)

ملخص

A library of anilinoanthraquinone derivatives was synthesized by parallel Ullmann coupling reaction of bromaminic acid with aniline derivatives in solution using a compact parallel synthesizer. The products were purified by HPLC and evaluated as antagonists at mouse and human P2Y2 receptors. 4-Phenylamino-substituted 1-amino-2-sulfoanthraquinones, for example, 1-amino-4-(2-methoxyphenyl)-2-sulfoanthraquinone (PSB-716), were potent P2Y2 antagonists with IC50 values in the low micromolar range.

اللغة الأصليةEnglish
الصفحات (من إلى)223-227
عدد الصفحات5
دوريةBioorganic and Medicinal Chemistry Letters
مستوى الصوت18
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرPublished - يناير 1 2008
منشور خارجيًانعم

ASJC Scopus subject areas

  • ???subjectarea.asjc.1300.1303???
  • ???subjectarea.asjc.1300.1313???
  • ???subjectarea.asjc.1300.1312???
  • ???subjectarea.asjc.3000.3003???
  • ???subjectarea.asjc.3000.3002???
  • ???subjectarea.asjc.1300.1308???
  • ???subjectarea.asjc.1600.1605???

بصمة

أدرس بدقة موضوعات البحث “Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا