Colorectal cancer patient characteristics, treatment and survival in Oman - A single center study

Shiyam Kumar*, Ikram A. Burney, Khawaja Farhan Zahid, Philomena Charlotte D. Souza, Muna Al Belushi, Taha Dawood Mufti, Waeil Al Meki, Muhammad Furrukh, Mansour S. Al Moundhri

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

38 اقتباسات (Scopus)


Background: Colorectal cancer is the most common gastrointestinal cancer in Oman with an increasing incidence. We here report the presenting features, treatment outcomes and survival in a University hospital in Oman and compare our data with regional and international studies. Materials and Methods: Medical records of patients with colorectal cancer were reviewed retrospectively between June 2000 and December 2013 and were followed until June 2014. Results: A total of 162 patients were diagnosed with colorectal cancer. The majority were males (58.6%), with a median age of 56 years. Rectum was involved in 29.6% of patients, followed by ascending and sigmoid colon. The majority of patients had stage III (42.6%) and stage IV (32.7%) disease at presentation. K-Ras status was checked for 79 patients, and 41 (51.9%) featured the wild type. Median relapse free survival was 22 months. Median overall survival for all patients was 43 months. Observed 5 year overall survival (OS) for stages I, II and III was 100%, 60% and 60% respectively. On Log rank univariate analysis, age, BMI, diabetes, hypertension, metformin use, stage, clinical nodal status for rectal cancer, pathological T and nodal status, site of metastasis, surgical intervention, chemotherapy, radiotherapy, chemotherapy regimen, no of cycles of chemotherapy, response, RFS, site of recurrence and administration of 2nd line chemotherapy were significant factors affecting OS. On Cox regression multivariate analysis none of the factors independently affected the OS. Conclusions: The majority of patients present with advanced disease and at young age. The survival rates are comparable to the published regional and international literature.

اللغة الأصليةEnglish
الصفحات (من إلى)4853-4858
عدد الصفحات6
دوريةAsian Pacific Journal of Cancer Prevention
مستوى الصوت16
رقم الإصدار12
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 2015

ASJC Scopus subject areas

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