TY - JOUR
T1 - Clinicopathological analysis and demographic features of ocular malignancies
AU - Al-Mujaini, Abdullah
AU - Maurya, Rajendra Prakash
AU - Bosak, Sanjay
AU - Karan, Manish Kumar
AU - Roy, Meghna
AU - Singh, Virendra Pratap
AU - Singh, Mahendra Kumar
AU - Kumar, Ajay
AU - Singh, Samer
N1 - Publisher Copyright:
© 2021 Al-Mujaini et al.
PY - 2021
Y1 - 2021
N2 - Objective: This study aimed to evaluate the epidemiological and clinicopathological spec-trum of ocular malignancies among patients presenting to a teaching hospital in Northern India. Methods: A total of 246 histopathologically diagnosed patients with ocular malignancies were included in the study. Tumor type and size, primary origin and location of tumor, clinical staging, radiological findings, histopathological type, and treatment outcomes were assessed. Results: Overall, males over 55 years of age were most commonly affected and the majority of cases were primary ocular or adnexal malignancies (n = 226; 91.87%). The eyelids and periocular structures (n = 92; 37.40%) were the most commonly involved site, followed by the orbit (n = 72; 29.27%), ocular surface (n = 46; 18.70%) and intraocular region (n = 36; 14.63%). The majority of the patients (n = 68; 27.64%) were managed by primary surgical excision and reconstruction. However, 46 patients (18.70%) with advanced lesions underwent neoadjuvant chemotherapy followed by surgical excision and more extensive orbital lesions were treated by exenteration followed by adjuvant chemotherapy (n=48; 19.51%), while patients with metastatic tumor were given palliative chemotherapy/external beam radiation therapy (n= 46; 18.70%). Overall, 45.12% of patients were cured completely, 15.45% showed a partial response to the treatment, 13.04% had progressive disease and 16.67% demonstrated disease recurrence. Conclusion: A clinicopathological analysis of ocular malignancies at a teaching hospital in Northern India indicated the preponderance of primary ocular malignancies, with eyelid sebaceous gland carcinomas being the most common pathological diagnosis. Most of our patients had advanced and extensive disease among them majority belonged to the rural background and poor socio-economic status.
AB - Objective: This study aimed to evaluate the epidemiological and clinicopathological spec-trum of ocular malignancies among patients presenting to a teaching hospital in Northern India. Methods: A total of 246 histopathologically diagnosed patients with ocular malignancies were included in the study. Tumor type and size, primary origin and location of tumor, clinical staging, radiological findings, histopathological type, and treatment outcomes were assessed. Results: Overall, males over 55 years of age were most commonly affected and the majority of cases were primary ocular or adnexal malignancies (n = 226; 91.87%). The eyelids and periocular structures (n = 92; 37.40%) were the most commonly involved site, followed by the orbit (n = 72; 29.27%), ocular surface (n = 46; 18.70%) and intraocular region (n = 36; 14.63%). The majority of the patients (n = 68; 27.64%) were managed by primary surgical excision and reconstruction. However, 46 patients (18.70%) with advanced lesions underwent neoadjuvant chemotherapy followed by surgical excision and more extensive orbital lesions were treated by exenteration followed by adjuvant chemotherapy (n=48; 19.51%), while patients with metastatic tumor were given palliative chemotherapy/external beam radiation therapy (n= 46; 18.70%). Overall, 45.12% of patients were cured completely, 15.45% showed a partial response to the treatment, 13.04% had progressive disease and 16.67% demonstrated disease recurrence. Conclusion: A clinicopathological analysis of ocular malignancies at a teaching hospital in Northern India indicated the preponderance of primary ocular malignancies, with eyelid sebaceous gland carcinomas being the most common pathological diagnosis. Most of our patients had advanced and extensive disease among them majority belonged to the rural background and poor socio-economic status.
KW - Diagnosis
KW - Neoadjuvant chemotherapy
KW - Ocular malignancy
KW - Primary cancer
KW - Sebaceous gland carcinoma
KW - Tumors
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U2 - 10.2147/OPTH.S287087
DO - 10.2147/OPTH.S287087
M3 - Article
C2 - 33542619
AN - SCOPUS:85100251994
SN - 1177-5467
VL - 15
SP - 357
EP - 365
JO - Clinical Ophthalmology
JF - Clinical Ophthalmology
ER -