TY - JOUR
T1 - Clinical and genetic characteristics of familial hypercholesterolemia at sultan qaboos university hospital in Oman
AU - Al-Waili, Khalid
AU - Al-Rasadi, Khalid
AU - Zadjali, Fahad
AU - Al-Hashmi, Khamis
AU - Al-Mukhaini, Suad
AU - Al-Kindi, Mohammed
AU - Al-Sabti, Hilal
AU - Al-Hinai, Ali Talib
AU - Farhan, Hatem
AU - Al-Zakwani, Ibrahim
N1 - The OMJ is Published Bimonthly and Copyrighted 2020 by the OMSB.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Objectives: We sought to describe the clinical and genetic characteristics of patients with familial hypercholesterolemia (FH) that presented to the lipid clinic at Sultan Qaboos University Hospital, Muscat, Oman.Methods: Patients who presented with high low-density lipoprotein cholesterol (LDL-C) levels (> 189.0 mg/dL or 4.9 mmol/L) were recruited to the study. FH was diagnosed according to the Dutch Lipid Clinic Network criteria. Analyses were performed using univariate statistics.Results: The study enrolled 450 patients with a mean age of 48.0±12.0 years, 56.0% (n = 252) were males and 11.3% (n = 51) were smokers. At admission, the proportion of 'probable/definite', 'possible', and 'unlikely' FH were 27.6% (n = 124), 70.0% (n = 315), and 2.4% (n = 11), respectively. Overall, 26.0% (n = 117) of patients had hypertension, 22.4% (n = 101) had a history of coronary artery disease, and 17.3% (n = 78) had diabetes mellitus. Those with 'probable/definite' FH were more likely to be prescribed high-intensity statin therapy (75.8% vs. 54.5%;
p < 0.001) and statin ezetimibe combination (50.8% vs. 27.3%;
p < 0.001) when compared to the 'unlikely' FH cohort. Additionally, those with very high atherosclerotic vascular disease (ASCVD) risk were also associated with high-intensity statin therapy (54.7% vs. 42.7%;
p = 0.006) and statin ezetimibe combination (26.4% vs. 17.2%;
p = 0.023). Patients with 'probable/definite' FH were less likely to achieve their LDL-C goal attainment compared to those with 'unlikely' FH (13.0% vs. 57.1%;
p < 0.001). Furthermore, those with very high ASCVD risk were less likely to achieve their LDL-C goals compared to the high ASCVD risk cohort (9.6% vs. 32.0%;
p < 0.001).
Conclusions: FH patients are underdiagnosed, undertreated, and less likely to attain their LDL-C goals in Oman.
AB - Objectives: We sought to describe the clinical and genetic characteristics of patients with familial hypercholesterolemia (FH) that presented to the lipid clinic at Sultan Qaboos University Hospital, Muscat, Oman.Methods: Patients who presented with high low-density lipoprotein cholesterol (LDL-C) levels (> 189.0 mg/dL or 4.9 mmol/L) were recruited to the study. FH was diagnosed according to the Dutch Lipid Clinic Network criteria. Analyses were performed using univariate statistics.Results: The study enrolled 450 patients with a mean age of 48.0±12.0 years, 56.0% (n = 252) were males and 11.3% (n = 51) were smokers. At admission, the proportion of 'probable/definite', 'possible', and 'unlikely' FH were 27.6% (n = 124), 70.0% (n = 315), and 2.4% (n = 11), respectively. Overall, 26.0% (n = 117) of patients had hypertension, 22.4% (n = 101) had a history of coronary artery disease, and 17.3% (n = 78) had diabetes mellitus. Those with 'probable/definite' FH were more likely to be prescribed high-intensity statin therapy (75.8% vs. 54.5%;
p < 0.001) and statin ezetimibe combination (50.8% vs. 27.3%;
p < 0.001) when compared to the 'unlikely' FH cohort. Additionally, those with very high atherosclerotic vascular disease (ASCVD) risk were also associated with high-intensity statin therapy (54.7% vs. 42.7%;
p = 0.006) and statin ezetimibe combination (26.4% vs. 17.2%;
p = 0.023). Patients with 'probable/definite' FH were less likely to achieve their LDL-C goal attainment compared to those with 'unlikely' FH (13.0% vs. 57.1%;
p < 0.001). Furthermore, those with very high ASCVD risk were less likely to achieve their LDL-C goals compared to the high ASCVD risk cohort (9.6% vs. 32.0%;
p < 0.001).
Conclusions: FH patients are underdiagnosed, undertreated, and less likely to attain their LDL-C goals in Oman.
KW - Acute Coronary Syndrome
KW - Arabs
KW - Cardiovascular Abnormalities
KW - Diabetes Mellitus
KW - Hypercholesterolemia
KW - Oman
UR - https://www.mendeley.com/catalogue/51bf4de3-46f7-3fc2-8aa7-d9fb0ef3f630/
U2 - 10.5001/omj.2020.59
DO - 10.5001/omj.2020.59
M3 - Article
C2 - 32704389
AN - SCOPUS:85090100783
SN - 1999-768X
VL - 35
SP - e141
JO - Oman Medical Journal
JF - Oman Medical Journal
IS - 3
M1 - e141
ER -