ملخص
(Chemical Equation Presented) The synthesis of N-substituted 5-nitroanthranilic acid derivatives 3a-w was achieved by a new, mild, microwave-assisted, regioselective amination reaction of 5-nitro-2-chlorobenzoic acid (1a) with a diverse range of aliphatic and aromatic amines 2a-w without added solvent or catalyst. Up to >99% isolated yield was obtained within 5-30 min at 80-120°C. The reaction, which is suitable for upscaling, yielded new compounds that are of considerable interest as useful building blocks and as potential drugs.
اللغة الأصلية | English |
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الصفحات (من إلى) | 5908-5911 |
عدد الصفحات | 4 |
دورية | Journal of Organic Chemistry |
مستوى الصوت | 72 |
رقم الإصدار | 15 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - يوليو 20 2007 |
منشور خارجيًا | نعم |
ASJC Scopus subject areas
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