Bone metabolism and histomorphometric changes in murine models treated with sclerostin antibody: A systematic review

Srijit Das, Rajalingham Sakthiswary*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

10 اقتباسات (Scopus)

ملخص

Preventing osteoporotic fractures in millions of individuals may significantly reduce the associated morbidity and health-care expenditures incurred. As such, the search for newer anti-osteoporotic agents has been ongoing for years. Genetic studies have proven that the secreted protein sclerostin is one of the main culprits, which negatively regulates the bone formation. Recently, sclerostin-neutralizing monoclonal antibodies (Scl-Ab) in rodent studies have shown positive effects on bone homeostasis. An extensive search of the literature was performed in the BIOSIS, Cinahl, EMBASE, Pub-Med, Web of Science and Cochrane Library databases to evaluate the published murine studies on the effects of Scl-Ab on the bone metabolism and histomorphometric parameters. Our systematic review depicts a significant association between Scl-Ab administration and improvement in bone formation, bone density, bone volume and trabecular thickness.

اللغة الأصليةEnglish
الصفحات (من إلى)1667-1674
عدد الصفحات8
دوريةCurrent Drug Targets
مستوى الصوت14
رقم الإصدار14
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 2013
منشور خارجيًانعم

ASJC Scopus subject areas

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بصمة

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