TY - JOUR
T1 - Atherogenic index of plasma and its cardiovascular risk factor correlates among patients with type 2 diabetes in Uganda
AU - Lumu, William
AU - Bahendeka, Silver
AU - Wesonga, Ronald
AU - Kibirige, Davis
AU - Kasoma, Ronald Mutebi
AU - Ssendikwanawa, Emmanuel
N1 - Publisher Copyright:
© 2023 Lumu W et al. Licensee African Health Sciences.
PY - 2023/4/11
Y1 - 2023/4/11
N2 - BACKGROUND: Atherogenic Index of Plasma (AIP) is a reliable predictor of coronary artery disease. There is paucity of data on AIP and its correlates among patients with type 2 diabetes (T2D) in Uganda.OBJECTIVE: To assess the profile of AIP and its cardiovascular risk factor correlates among patients with T2D in Uganda.METHODS: This was a cross-sectional study conducted in 8 health facilities with established T2D clinics in Central-Uganda. The study enrolled 500 patients aged 40 to 79 years. Data was collected on socio-demographic characteristics, lipid profile and glycated haemoglobin (HbA1c). The AIP was derived using log (triglycerides/high-density cholesterol) and further categorised as low cardiovascular disease (CVD) risk if the AIP was <0.1, intermediate risk (0.1-0.24) and high risk (≥0.24). Cardiovascular risk factors were defined according to international guidelines.Stata version 14 was used to analyse data, Pearson correlation analyses were conducted. Statistical significance was set at p<0.05.RESULTS: There were 389(77.4%) females with a mean age of 55.07±8. 979 years. Low-risk was found in 43.6%, intermediate risk in 20.2% and high risk in 36.2% of the participants. AIP significantly correlated with waist circumference (r=0.1095, p<0.0147), waist-hip ratio (r=0.1926, p<0.001), Casteri Risk Index I (r=0.506, r=<0.001), Casteri Risk Index II (r=0.246, p<0.001) and atherogenic coefficient (r=0.186, p<0.001). Insignificant correlation was observed between AIP and fasting blood sugar (r=0.017, p=0.7042), HBA1C (r=0.0108, p=0.8099) and diabetes duration (r=0.0445, p=0.32).CONCLUSIONS: AIP is significantly elevated and correlated with cardiovascular risk factors in patients with T2D. In clinical management, this may be a useful tool in risk stratifying patients with T2D.
AB - BACKGROUND: Atherogenic Index of Plasma (AIP) is a reliable predictor of coronary artery disease. There is paucity of data on AIP and its correlates among patients with type 2 diabetes (T2D) in Uganda.OBJECTIVE: To assess the profile of AIP and its cardiovascular risk factor correlates among patients with T2D in Uganda.METHODS: This was a cross-sectional study conducted in 8 health facilities with established T2D clinics in Central-Uganda. The study enrolled 500 patients aged 40 to 79 years. Data was collected on socio-demographic characteristics, lipid profile and glycated haemoglobin (HbA1c). The AIP was derived using log (triglycerides/high-density cholesterol) and further categorised as low cardiovascular disease (CVD) risk if the AIP was <0.1, intermediate risk (0.1-0.24) and high risk (≥0.24). Cardiovascular risk factors were defined according to international guidelines.Stata version 14 was used to analyse data, Pearson correlation analyses were conducted. Statistical significance was set at p<0.05.RESULTS: There were 389(77.4%) females with a mean age of 55.07±8. 979 years. Low-risk was found in 43.6%, intermediate risk in 20.2% and high risk in 36.2% of the participants. AIP significantly correlated with waist circumference (r=0.1095, p<0.0147), waist-hip ratio (r=0.1926, p<0.001), Casteri Risk Index I (r=0.506, r=<0.001), Casteri Risk Index II (r=0.246, p<0.001) and atherogenic coefficient (r=0.186, p<0.001). Insignificant correlation was observed between AIP and fasting blood sugar (r=0.017, p=0.7042), HBA1C (r=0.0108, p=0.8099) and diabetes duration (r=0.0445, p=0.32).CONCLUSIONS: AIP is significantly elevated and correlated with cardiovascular risk factors in patients with T2D. In clinical management, this may be a useful tool in risk stratifying patients with T2D.
KW - Atherogenic index of plasma
KW - Type 2 diabetes
KW - Uganda
KW - cardiovascular risk factors
KW - Cross-Sectional Studies
KW - Humans
KW - Middle Aged
KW - Cardiovascular Diseases/epidemiology
KW - Risk Factors
KW - Uganda/epidemiology
KW - Male
KW - Glycated Hemoglobin
KW - Triglycerides
KW - Diabetes Mellitus, Type 2/complications
KW - Atherosclerosis/epidemiology
KW - Female
KW - Heart Disease Risk Factors
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UR - https://www.mendeley.com/catalogue/c5b2ef87-7ea6-30fd-96e7-361869fa330e/
U2 - 10.4314/ahs.v23i1.54
DO - 10.4314/ahs.v23i1.54
M3 - Article
C2 - 37545918
AN - SCOPUS:85156133258
SN - 1680-6905
VL - 23
SP - 515
EP - 527
JO - African Health Sciences
JF - African Health Sciences
IS - 1
ER -