TY - JOUR
T1 - Antioxidative capacity of hydrochlorothiazide and atenolol in long-term hypertension therapy
AU - Sankar, Devarajan
AU - Ali, Amanat
AU - Raman, Saraswathi
AU - Uehara, Yoshmari
AU - Ganapathy, Sambandam
PY - 2010/3
Y1 - 2010/3
N2 - Objective: To study the antioxidative prospective of diuretics (hydrochlorothiazide) or β-blockers (atenolol) in long-term hypertension therapy. Methods: Enzymatic and non-enzymatic antioxidants , and lipid peroxidation in blood was measured in hypertensive patients on long-term medication with either diuretics or β-blockers , and they were compared with agematched untreated hypertensive patients , and normal subjects. Results: Plasma levels of lipid peroxidation as thiobarbituric acid reactive substances (TBARS) in untreated hypertensive patients were significantly (P < 0. 05) higher while the levels of enzymatic and non-enzymatic antioxidants were significantly lower (P < 0. 05) as compared to hypertensive patients with medication,and normal subjects. Between the two drug treated hypertensive groups, although no significant (P < 0.05) differences were observed in blood pressure , a significant improvement in the status of enzymatic ( superoxide dismutase , catalase and glutathione peroxidase) and non-enzymatic (vitamin C , vitamin E , β-carotene and reduced glutathione) antioxidants were observed in atenolol treated group compared to untreated hypertensive patients , and patients treated with hydrochlorothiazide. Conclusion: The results of the present study suggest that atenolol has better antioxidative capacity by protecting the enzymatic and non-enzymatic antioxidants when compared with hydrochlorothiazide therapy.
AB - Objective: To study the antioxidative prospective of diuretics (hydrochlorothiazide) or β-blockers (atenolol) in long-term hypertension therapy. Methods: Enzymatic and non-enzymatic antioxidants , and lipid peroxidation in blood was measured in hypertensive patients on long-term medication with either diuretics or β-blockers , and they were compared with agematched untreated hypertensive patients , and normal subjects. Results: Plasma levels of lipid peroxidation as thiobarbituric acid reactive substances (TBARS) in untreated hypertensive patients were significantly (P < 0. 05) higher while the levels of enzymatic and non-enzymatic antioxidants were significantly lower (P < 0. 05) as compared to hypertensive patients with medication,and normal subjects. Between the two drug treated hypertensive groups, although no significant (P < 0.05) differences were observed in blood pressure , a significant improvement in the status of enzymatic ( superoxide dismutase , catalase and glutathione peroxidase) and non-enzymatic (vitamin C , vitamin E , β-carotene and reduced glutathione) antioxidants were observed in atenolol treated group compared to untreated hypertensive patients , and patients treated with hydrochlorothiazide. Conclusion: The results of the present study suggest that atenolol has better antioxidative capacity by protecting the enzymatic and non-enzymatic antioxidants when compared with hydrochlorothiazide therapy.
KW - Antioxidants
KW - Atenolol
KW - Hydrochlorothiazide
KW - Lipid peroxidation
KW - Oxidative stress
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M3 - Article
AN - SCOPUS:77953422245
SN - 1562-9023
VL - 5
SP - 123
EP - 129
JO - Journal of Chinese Clinical Medicine
JF - Journal of Chinese Clinical Medicine
IS - 3
ER -