Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device

Haider A.J. Al Lawati*, Zeiyana M. Al Dahmani, Fakhr Eldin O. Suliman, Salma M.Z. Al Kindy, Ali M. Al-Lawati

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

18 اقتباسات (Scopus)

ملخص

A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10- phenanthroline)-ruthenium(II) [Ru(phen)32+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 μg/mL was obtained. The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.

اللغة الأصليةEnglish
الصفحات (من إلى)762-767
عدد الصفحات6
دوريةLuminescence
مستوى الصوت26
رقم الإصدار6
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 2011

ASJC Scopus subject areas

  • ???subjectarea.asjc.1300.1304???
  • ???subjectarea.asjc.1600.1601???

بصمة

أدرس بدقة موضوعات البحث “Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا