TY - JOUR
T1 - An ICET-A survey on occult and emerging endocrine complications in patients with β-thalassemia major
T2 - Conclusions and recommendations
AU - De Sanctis, Vincenzo
AU - Soliman, Ashraf T.
AU - Canatan, Duran
AU - Tzoulis, Ploutarchos
AU - Daar, Shahina
AU - Di Maio, Salvatore
AU - Elsedfy, Heba
AU - Yassin, Mohamed A.
AU - Filosa, Aldo
AU - Soliman, Nada
AU - Karimi, Mehran
AU - Saki, Forough
AU - Sobti, Praveen
AU - Kakkar, Shruti
AU - Christou, Soteroula
AU - Albu, Alice
AU - Christodoulides, Constantinos
AU - Kilinc, Yurdanur
AU - Al Jaouni, Soad
AU - Khater, Doaa
AU - Alyaarubi, Saif A.
AU - Lum, Su Han
AU - Campisi, Saveria
AU - Anastasi, Salvatore
AU - Galati, Maria Concetta
AU - Raiola, Giuseppe
AU - Wali, Yasser
AU - Elhakim, Ihab Z.
AU - Mariannis, Demetris
AU - Ladis, Vassilis
AU - Kattamis, Christos
N1 - Publisher Copyright:
© Mattioli 1885.
PY - 2018/1/17
Y1 - 2018/1/17
N2 - In adult thalassemia major (TM) patients, a number of occult and emerging endocrine complications, such as: central hypothyroidism (CH), thyroid cancer, latent hypocortisolism, and growth hormone deficiency (GHD) have emerged and been reported. As the early detection of these complications is essential for appropriate treatment and follow-up, the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescent Medicine (ICET-A) promoted a survey on these complications in adult TM patients, among physicians (pediatricians, hematologists and endocrinologists) caring for TM patients in different countries. The data reported by 15 countries are presented.The commonest endocrine complications registered in 3.114 TM adults are CH and GHD (4.6 % and 3.0 %, respectively), followed by latent hypocortisolism (1.2%). In 13 patients (0.41%) a cytological papillary or follicular thyroid carcinoma was diagnosed in 11 and 2 patients, respectively, and a lobectomy or thyroidectomy was carried out. Of 202 TM patients below the age of 18 years, the reported endocrine complications were: GHD in 4.5%, latent hypocortisolism in 4.4% and central hypothyrodisim in 0.5%. Transition phase was an area of interest for many clinicians, especially as patients with complex chronic health conditions are responding to new treatments extending their lifespan beyond imagination.. In conclusion, our survey provides a better understanding of physicians’ current clinical practices and beliefs in the detection, prevention and treatment of some endocrine complications prevailing in adult TM patients. Regular surveillance, early diagnosis, treatment and follow-up in a multi-disciplinary specialized setting are recommended. (www.actabiomedica.it).
AB - In adult thalassemia major (TM) patients, a number of occult and emerging endocrine complications, such as: central hypothyroidism (CH), thyroid cancer, latent hypocortisolism, and growth hormone deficiency (GHD) have emerged and been reported. As the early detection of these complications is essential for appropriate treatment and follow-up, the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescent Medicine (ICET-A) promoted a survey on these complications in adult TM patients, among physicians (pediatricians, hematologists and endocrinologists) caring for TM patients in different countries. The data reported by 15 countries are presented.The commonest endocrine complications registered in 3.114 TM adults are CH and GHD (4.6 % and 3.0 %, respectively), followed by latent hypocortisolism (1.2%). In 13 patients (0.41%) a cytological papillary or follicular thyroid carcinoma was diagnosed in 11 and 2 patients, respectively, and a lobectomy or thyroidectomy was carried out. Of 202 TM patients below the age of 18 years, the reported endocrine complications were: GHD in 4.5%, latent hypocortisolism in 4.4% and central hypothyrodisim in 0.5%. Transition phase was an area of interest for many clinicians, especially as patients with complex chronic health conditions are responding to new treatments extending their lifespan beyond imagination.. In conclusion, our survey provides a better understanding of physicians’ current clinical practices and beliefs in the detection, prevention and treatment of some endocrine complications prevailing in adult TM patients. Regular surveillance, early diagnosis, treatment and follow-up in a multi-disciplinary specialized setting are recommended. (www.actabiomedica.it).
KW - Central hypothyroidism
KW - Growth hormone deficienctransition phase
KW - ICET-A
KW - Latent hypocortisolism
KW - Thalassemia major
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U2 - 10.23750/abm.v89i4.7774
DO - 10.23750/abm.v89i4.7774
M3 - Article
C2 - 30657116
AN - SCOPUS:85060157088
SN - 0392-4203
VL - 89
SP - 481
EP - 489
JO - Acta Biomedica
JF - Acta Biomedica
IS - 4
ER -