TY - JOUR
T1 - Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice
AU - Venkatesh Gobi, Veerappan
AU - Rajasankar, Srinivasagam
AU - Ramkumar, Muthu
AU - Dhanalakshmi, Chinnasamy
AU - Manivasagam, Thamilarasan
AU - Justin Thenmozhi, Arokiasamy
AU - Essa, Musthafa Mohamed
AU - Chidambaram, Ranganathan
AU - Kalandar, Ameer
N1 - Publisher Copyright:
© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/10/21
Y1 - 2018/10/21
N2 - Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson’s disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A. blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1 mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200 mg/kg b.w.), and treated with A. blazei alone (200 mg/kg b.w.). After the end of the experimental period, behavioral studies, biochemical estimations, and protein expression patterns of inflammatory markers were studied. Rotenone treatment exhibited enhanced motor impairments, neurochemical deficits, oxidative stress, and inflammation, whereas oral administration of A. blazei extract attenuated the above-said indices. Even though further research is needed to prove its efficacy in clinical studies, the results of our study concluded that A. blazei extract offers a promising and new therapeutic lead for treatment of PD.
AB - Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson’s disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A. blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1 mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200 mg/kg b.w.), and treated with A. blazei alone (200 mg/kg b.w.). After the end of the experimental period, behavioral studies, biochemical estimations, and protein expression patterns of inflammatory markers were studied. Rotenone treatment exhibited enhanced motor impairments, neurochemical deficits, oxidative stress, and inflammation, whereas oral administration of A. blazei extract attenuated the above-said indices. Even though further research is needed to prove its efficacy in clinical studies, the results of our study concluded that A. blazei extract offers a promising and new therapeutic lead for treatment of PD.
KW - Agaricus blazei
KW - Dopamine
KW - Neurodegenerative disease
KW - Neuroinflammation
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85021126616&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021126616&partnerID=8YFLogxK
U2 - 10.1080/1028415X.2017.1337290
DO - 10.1080/1028415X.2017.1337290
M3 - Article
C2 - 28628424
AN - SCOPUS:85021126616
SN - 1028-415X
VL - 21
SP - 657
EP - 666
JO - Nutritional Neuroscience
JF - Nutritional Neuroscience
IS - 9
ER -