Acute toxicity of samorin (Isometamidium chloride) in rabbits

B. H. Ali*, E. M. Haroun

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

2 اقتباسات (Scopus)

ملخص

1. Oral administration of samorin (isometamidium chloride) to rabbits in single oral doses of 6.25, 12.5, 25 and 50 mg/kg produced signs of toxicity which were dose-dependent. These were restlessness, hyperaesthesia, tremors, convulsions and finally death. 2. Post mortem examination revealed fatty change, congestion and haemorrhage in many organs. Histopathological examination of liver, brain, kidneys and lungs showed severe circulatory changes and cellular damage. Measurement of serum constituents confirmed the presence of hepatic and renal damage. 3. Samorin produced a marked fall in the erythrocyte count and the haematocrit values of all the treated rabbits, and in doses of 25 and 50 mg/kg it also increased the osmotic fragility of the erythrocytes.

اللغة الأصليةEnglish
الصفحات (من إلى)419-423
عدد الصفحات5
دوريةComparative Biochemistry and Physiology. Part C, Comparative
مستوى الصوت78
رقم الإصدار2
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 1984

ASJC Scopus subject areas

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