Abnormal soluble CD40 ligand and C-reactive protein concentrations in hypertension: Relationship to indices of angiogenesis

Jeetesh V. Patel, Sern Lim Hoong, Sunil Nadar, Muzahir Tayebjee, Elizabeth A. Hughes, Gregory Y.H. Lip*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

31 اقتباسات (Scopus)

ملخص

Background: Abnormal inflammation, platelets and angiogenesis are involved in the pathophysiology of cardiovascular disease (CVD). Objective: To test the hypothesis that concentrations of high sensitive C-reactive protein (CRP, an index of inflammation) and soluble CD40 ligand (sCD40L, an index of platelet activation) would be abnormal in hypertension, and in turn, be related to plasma indices of angiogenesis, the angiopoietins-1 and -2, and vascular endothelial growth factor (VEGF), in addition to the presence or absence of CVD. Methods: Using a cross-sectional approach, we measured plasma concentrations of CRP, sCD40L, VEGF, and angiopoietins-1 and -2 in 147 patients with hypertension (85 with a history of CVD event/s, 62 CVD event-free) and 68 age- and sex-matched healthy controls. Results: Concentrations of sCD40L (P = 0.039), CRP (P < 0.001), angiopoietin-1 (P < 0.001), angiopoietin-2 (P = 0.003) and VEGF (P < 0.001) were all greater amongst hypertensive patients than in controls. There were no significant differences in sCD40L and VEGF concentrations between hypertensive individuals with and without CVD events, but CRP and angiopoietin-1 concentrations were significantly greater amongst those with CVD events. On multiple regression analysis, sCD40L was associated with angiopoietin-2 (P = 0.01) and VEGF (P = 0.007) in hypertensive individuals, but no such associations were found within the healthy control group. Conclusion: In patients with hypertension, sCD40L was associated with increased circulating markers of abnormal angiogenesis (angiopoietin-2, VEGF). The interaction between sCD40L and angiogenesis may contribute to the pathophysiology of CVD in hypertension.

اللغة الأصليةEnglish
الصفحات (من إلى)117-121
عدد الصفحات5
دوريةJournal of Hypertension
مستوى الصوت24
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرPublished - يناير 2006
منشور خارجيًانعم

ASJC Scopus subject areas

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  • ???subjectarea.asjc.1300.1314???
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بصمة

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