TY - JOUR
T1 - A solid-state electrochemiluminescence composite modified electrode based on Ru(bpy)32+/PAHNSA
T2 - Characterization and pharmaceutical applications
AU - Al-Hinaai, Mohammed
AU - Khudaish, Emad A.
AU - Al-Harthy, Salim
AU - Suliman, Fakhr Eldin O.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/7/15
Y1 - 2015/7/15
N2 - Abstract A composite electrochemiluminescence (ECL) sensor was constructed by electrochemical polymerization of 4-amino-3-hydroxynaphthalene sulfonic acid (AHNSA) and tris(2,2′-bipyridyl) ruthenium(II), [Ru(bpy)3]2+, from their aqueous solutions at glassy carbon electrode (GCE). The proposed one-step electrochemical synthesis of the composite film (Ru/PAHNSA/GCE) provides a stable and reactive luminescent for the quantification of chlorpheniramine maleate (CPM) in its pharmaceutical preparations. The properties and the structure of the modified surface were studied using typical voltammetric, Electrochemical Impedance Spectroscopy (EIS), X-Ray Photoelectron Spectroscopy (XPS) and Atomic Force Microscopy (AFM) methods. The intensity of the ECL as a function of [CPM] is linear for the range between 0.2 and 32 μg mL-1 with a detection limit of 0.023 μg mL-1. The performance of the sensor was tested in the presence of interference species and for real sample analysis under optimal conditions.
AB - Abstract A composite electrochemiluminescence (ECL) sensor was constructed by electrochemical polymerization of 4-amino-3-hydroxynaphthalene sulfonic acid (AHNSA) and tris(2,2′-bipyridyl) ruthenium(II), [Ru(bpy)3]2+, from their aqueous solutions at glassy carbon electrode (GCE). The proposed one-step electrochemical synthesis of the composite film (Ru/PAHNSA/GCE) provides a stable and reactive luminescent for the quantification of chlorpheniramine maleate (CPM) in its pharmaceutical preparations. The properties and the structure of the modified surface were studied using typical voltammetric, Electrochemical Impedance Spectroscopy (EIS), X-Ray Photoelectron Spectroscopy (XPS) and Atomic Force Microscopy (AFM) methods. The intensity of the ECL as a function of [CPM] is linear for the range between 0.2 and 32 μg mL-1 with a detection limit of 0.023 μg mL-1. The performance of the sensor was tested in the presence of interference species and for real sample analysis under optimal conditions.
KW - Chlorpheniramine maleate
KW - Key words Electrochemiluninescence
KW - Poly(4-amino-3-hydroxynaphthalene sulfonic acid)
KW - Sensors
KW - Tris(bipyridyl)ruthenium(II)
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U2 - 10.1016/j.electacta.2015.06.148
DO - 10.1016/j.electacta.2015.06.148
M3 - Article
AN - SCOPUS:84937575986
SN - 0013-4686
VL - 176
SP - 179
EP - 187
JO - Electrochimica Acta
JF - Electrochimica Acta
M1 - 25273
ER -