ملخص
A simple, rapid, solvent-free, room temperature one pot synthesis of benzene ring acylated and demethylated analogues of harmine using acyl halides/acid anhydrides and AlCl3 has been developed. Eight different acyl halides/acid anhydrides were used in the synthesis. The resulting mixture of products was separated by column chromatography to afford 10- and 12-monoacyl analogues, along with 10,12-diacyl-11-hydroxy products. In five cases the corresponding 10-acyl-11-hydroxy analogues were also obtained. Yields from the eight syntheses (29 products in total) were in the 6-34% range and all compounds were fully characterized.
اللغة الأصلية | English |
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الصفحات (من إلى) | 1584-1598 |
عدد الصفحات | 15 |
دورية | Molecules |
مستوى الصوت | 13 |
رقم الإصدار | 8 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - أغسطس 2008 |
منشور خارجيًا | نعم |
ASJC Scopus subject areas
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- ???subjectarea.asjc.3000.3003???
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- ???subjectarea.asjc.1600.1606???
- ???subjectarea.asjc.1600.1605???