ملخص
2-(2'-Hydroxyphenyl)benzoxazole (HBO) undergoes rapid photoinduced proton transfer from the enol-imine to the keto-amine tautomer. When incorporated in duplex DNA opposite an abasic site, HBO appears to be a good mimic of a natural DNA base pair based on duplex stability, UV and CD spectroscopy, and molecular dynamics simulations. In the chosen sequence context, HBO exists exclusively as the syn-enol tautomer, which is consistent with an environment of the model base that is dominated by neighboring nucleobases and not by solvation. The syn-enol efficiently undergoes photoinduced proton transfer to the keto-tautomer, which should allow for the study of tautomerization within the duplex DNA.
اللغة الأصلية | English |
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الصفحات (من إلى) | 9917-9920 |
عدد الصفحات | 4 |
دورية | Journal of the American Chemical Society |
مستوى الصوت | 122 |
رقم الإصدار | 41 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - أكتوبر 18 2000 |
منشور خارجيًا | نعم |
ASJC Scopus subject areas
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