1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

R. J. Abdel-Jalil; M. Übele; W. Ehrlichmann; W. Voelter; H. J. Machulla

doi:10.1007/s10967-006-0086-9

1-[¹⁸F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

R. J. Abdel-Jalil^*, M. Übele, W. Ehrlichmann, W. Voelter, H. J. Machulla

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نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

7 اقتباسات (Scopus)

ملخص

1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and ¹⁸F labeling gave the corresponding markers in 70-82% radiochemical yield.

اللغة الأصلية	English
الصفحات (من إلى)	557-560
عدد الصفحات	4
دورية	Journal of Radioanalytical and Nuclear Chemistry
مستوى الصوت	267
رقم الإصدار	3
المعرِّفات الرقمية للأشياء	https://doi.org/10.1007/s10967-006-0086-9
حالة النشر	Published - مايو 2006
منشور خارجيًا	نعم

ASJC Scopus subject areas

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10.1007/s10967-006-0086-9

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قم بذكر هذا

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title = "1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers",

abstract = "1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82% radiochemical yield.",

author = "Abdel-Jalil, {R. J.} and M. {\"U}bele and W. Ehrlichmann and W. Voelter and Machulla, {H. J.}",

note = "Funding Information: Financial support, provided by the Hashemite University, is greatly acknowledged. R.A.-J thanks DAAD (Bonn, Germany) for a research visit fellowship. This work is part of a research project funded by Deutsche Forschungsgemeinschaft (DFG), Grant Number PI 242/3-1.",

year = "2006",

month = may,

doi = "10.1007/s10967-006-0086-9",

language = "English",

volume = "267",

pages = "557--560",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

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T1 - 1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

AU - Abdel-Jalil, R. J.

AU - Übele, M.

AU - Ehrlichmann, W.

AU - Voelter, W.

AU - Machulla, H. J.

N1 - Funding Information: Financial support, provided by the Hashemite University, is greatly acknowledged. R.A.-J thanks DAAD (Bonn, Germany) for a research visit fellowship. This work is part of a research project funded by Deutsche Forschungsgemeinschaft (DFG), Grant Number PI 242/3-1.

PY - 2006/5

Y1 - 2006/5

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AB - 1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82% radiochemical yield.

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